{"id":5340,"date":"2026-08-21T15:33:54","date_gmt":"2026-08-21T18:33:54","guid":{"rendered":"https:\/\/overticeportal.com.br\/?p=5340"},"modified":"2026-08-21T15:34:00","modified_gmt":"2026-08-21T18:34:00","slug":"celulas-tronco-do-nariz-abrem-caminho-para-tratar-lesoes-na-medula-espinhal","status":"publish","type":"post","link":"https:\/\/www.portalam9.com.br\/?p=5340","title":{"rendered":"C\u00e9lulas-tronco do nariz abrem caminho para tratar les\u00f5es na medula espinhal"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Tempo de leitura: 1 minuto<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pesquisadores de diferentes centros da USP (Universidade de S\u00e3o Paulo) desenvolveram uma terapia experimental que utiliza&nbsp;<strong>c\u00e9lulas-tronco<\/strong>&nbsp;da mucosa olfativa para tratar&nbsp;<strong>les\u00f5es na medula espinhal<\/strong>. Os testes, realizados em modelos animais, demonstraram uma recupera\u00e7\u00e3o significativa das fun\u00e7\u00f5es motoras nas cobaias.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A pesquisa focou nas&nbsp;<strong>c\u00e9lulas ectomesenquimais<\/strong>, que s\u00e3o respons\u00e1veis pela regenera\u00e7\u00e3o cont\u00ednua do sistema olfativo. De acordo com os cientistas, essas c\u00e9lulas s\u00e3o obtidas por meio de procedimentos pouco invasivos, superando limita\u00e7\u00f5es associadas ao isolamento de c\u00e9lulas-tronco de cord\u00e3o umbilical ou de medula \u00f3ssea.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Experimento e mecanismo de regenera\u00e7\u00e3o neurol\u00f3gica<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">No modelo experimental com ratos Wistar, o grupo que recebeu a inje\u00e7\u00e3o dessas c\u00e9lulas associada a um composto biol\u00f3gico gelatinoso (Matrigel) voltou a andar na terceira semana ap\u00f3s a contus\u00e3o medular.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O estudo revelou que, ao contr\u00e1rio das teorias anteriores, as c\u00e9lulas-tronco transplantadas n\u00e3o preenchem fisicamente o local lesionado para criar uma nova via de condu\u00e7\u00e3o nervosa. Em vez disso, elas atuam recrutando e gerando subst\u00e2ncias que estimulam a\u00a0<strong>regenera\u00e7\u00e3o neuronal<\/strong>\u00a0na pr\u00f3pria regi\u00e3o afetada.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pr\u00f3ximos passos e testes cl\u00ednicos<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Embora os resultados sejam preliminares e restritos a testes laboratoriais em animais, o avan\u00e7o abre perspectivas para o desenvolvimento de\u00a0<strong>futuros tratamentos em humanos<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A pesquisa foi conduzida pelo m\u00e9dico Brian Coimbra, em sua tese de doutorado na Faculdade de Medicina da USP (FMUSP), sob orienta\u00e7\u00e3o do professor Alexandre Foga\u00e7a. O grupo agora busca aprofundar a compreens\u00e3o dos mecanismos moleculares para viabilizar a transi\u00e7\u00e3o da terapia para\u00a0<strong>ensaios cl\u00ednicos<\/strong>\u00a0e o poss\u00edvel desenvolvimento de f\u00e1rmacos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Foto: CDC\/Pexels | Fonte: CNN Brasil <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tempo de leitura: 1 minuto Pesquisadores de diferentes centros da USP (Universidade de S\u00e3o Paulo)<\/p>\n","protected":false},"author":3,"featured_media":5341,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[39],"class_list":["post-5340","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brasil","tag-destaque"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>C\u00e9lulas-tronco do nariz abrem caminho para tratar les\u00f5es na medula espinhal - 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