{"id":4279,"date":"2025-12-05T12:52:08","date_gmt":"2025-12-05T15:52:08","guid":{"rendered":"https:\/\/overticeportal.com.br\/?p=4279"},"modified":"2025-12-05T12:52:10","modified_gmt":"2025-12-05T15:52:10","slug":"gene-unico-pode-estar-ligado-a-doencas-mentais-sugere-estudo","status":"publish","type":"post","link":"https:\/\/www.portalam9.com.br\/?p=4279","title":{"rendered":"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo"},"content":{"rendered":"\n

Tempo de leitura: 3 minutos <\/em><\/p>\n\n\n\n

Um grupo de psiquiatras da Universidade de Leipzig, na Alemanha, descobriu que um \u00fanico gene pode estar associado a doen\u00e7as mentais. Anteriormente, a medicina acreditava que todos os transtornos ps\u00edquicos eram produto de uma combina\u00e7\u00e3o de fatores gen\u00e9ticos e ambientais, mas segundo os pesquisadores alem\u00e3es, a altera\u00e7\u00e3o de apenas uma parte do DNA pode estar por tr\u00e1s de casos de esquizofrenia, transtornos de ansiedade ou depress\u00e3o.<\/p>\n\n\n\n

Os psiquiatras analisaram muta\u00e7\u00f5es no gene GRIN2A e encontraram uma liga\u00e7\u00e3o direta entre altera\u00e7\u00f5es nele e sintomas psiqui\u00e1tricos em pacientes humanos. A equipe avaliou 121 indiv\u00edduos e observou diagn\u00f3sticos que inclu\u00edam transtornos de humor, ansiedade e quadros psic\u00f3ticos. Os resultados da pesquisa foram publicados em outubro na revista Nature Molecular Psychiatry.<\/p>\n\n\n\n

O resultado n\u00e3o significa que todas as pessoas com doen\u00e7as mentais tenham essa altera\u00e7\u00e3o do DNA, mas que ela pode ser uma forma de manifesta\u00e7\u00e3o, a \u00fanica com uma origem t\u00e3o facilmente identific\u00e1vel, e que pode estar por tr\u00e1s\u00a0especialmente de manifesta\u00e7\u00f5es precoces dessas doen\u00e7as.<\/p>\n\n\n\n

Durante o estudo, crian\u00e7as e adolescentes apresentaram altera\u00e7\u00f5es comportamentais antes da fase em que esses transtornos costumam surgir na popula\u00e7\u00e3o geral. Casos isolados exibiram apenas sinais psiqui\u00e1tricos, sem condi\u00e7\u00f5es neurol\u00f3gicas de comprometimento cognitivo associadas.<\/p>\n\n\n\n

\n

\u201cConseguimos demonstrar que certas variantes desse gene est\u00e3o associadas n\u00e3o apenas \u00e0 esquizofrenia, mas tamb\u00e9m a outras doen\u00e7as mentais. O que chama a aten\u00e7\u00e3o \u00e9 que, no contexto de uma altera\u00e7\u00e3o no GRIN2A , esses transtornos j\u00e1 se manifestam na inf\u00e2ncia ou adolesc\u00eancia em contraste com a manifesta\u00e7\u00e3o mais t\u00edpica na idade adulta\u201d, afirma o professor Johannes Lemke, geneticista l\u00edder do estudo.<\/p>\n<\/blockquote>\n\n\n\n

Como foi feito o estudo?<\/h2>\n\n\n\n

Para o estudo, a equipe criou um registro internacional com o maior grupo global de pacientes com altera\u00e7\u00f5es no GRIN2A. O banco reuniu diferentes n\u00edveis de variantes classificadas como provavelmente causadoras de dist\u00farbios, inclusive muta\u00e7\u00f5es nulas que sugerem perda de fun\u00e7\u00e3o do gene.<\/p>\n\n\n\n

Os pesquisadores encontraram 25 indiv\u00edduos com diagn\u00f3sticos psiqui\u00e1tricos entre os 121 analisados. Os quadros inclu\u00edram transtornos alimentares, ansiosos e de personalidade. A distribui\u00e7\u00e3o refor\u00e7ou a hip\u00f3tese de que a altera\u00e7\u00e3o gen\u00e9tica tem impacto direto na sa\u00fade mental.<\/p>\n\n\n\n

Novos tratamentos com base no gene<\/h2>\n\n\n\n

O gene GRIN2A participa do controle da atividade el\u00e9trica neuronal. Muta\u00e7\u00f5es nele reduzem a a\u00e7\u00e3o do receptor NMDA e alteram a transmiss\u00e3o de sinais no c\u00e9rebro. Como a maioria dos transtornos mentais leva a essas altera\u00e7\u00f5es nas sinapses, os m\u00e9dicos decidiram avaliar se tratamentos experimentais poderiam beneficiar pessoas com a muta\u00e7\u00e3o.<\/p>\n\n\n\n

No estudo, quatro indiv\u00edduos receberam doses de L-serina, um suplemento alimentar que \u00e9 conhecido por ativar receptores de glutamato e \u00e9 usado para controlar convuls\u00f5es. Todos os pacientes mostraram melhora em sintomas psiqui\u00e1tricos ao us\u00e1-lo. Um deles interrompeu totalmente as alucina\u00e7\u00f5es do dist\u00farbio.<\/p>\n\n\n\n

Como funcionam os antidepressivos? Manual do usu\u00e1rio<\/h2>\n\n\n\n

Os demais apresentaram remiss\u00e3o de sintomas paranoicos e redu\u00e7\u00e3o de crises. A amostra pequena limita conclus\u00f5es, mas sugere que parte dos transtornos pode responder a interven\u00e7\u00f5es precisas baseadas em perfis gen\u00e9ticos espec\u00edficos.<\/p>\n\n\n\n

Os pesquisadores indicam a necessidade de ampliar as an\u00e1lises sobre o impacto funcional do gene. A equipe acredita, por\u00e9m, que a altera\u00e7\u00e3o pode definir um subgrupo de transtornos com origem molecular clara e curso distinto daqueles com ra\u00edzes multifatoriais.<\/p>\n\n\n\n

Fonte: Metr\u00f3poles \/ <\/strong>Foto: Getty unages\/Josh Hawley
<\/em>
<\/p>\n","protected":false},"excerpt":{"rendered":"

Tempo de leitura: 3 minutos Um grupo de psiquiatras da Universidade de Leipzig, na Alemanha,<\/p>\n","protected":false},"author":3,"featured_media":4280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[],"class_list":["post-4279","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"\nGene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo - Portal Amazonas 9<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/portalam9.com.br\/?p=4279\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo - Portal Amazonas 9\" \/>\n<meta property=\"og:description\" content=\"Tempo de leitura: 3 minutos Um grupo de psiquiatras da Universidade de Leipzig, na Alemanha,\" \/>\n<meta property=\"og:url\" content=\"https:\/\/portalam9.com.br\/?p=4279\" \/>\n<meta property=\"og:site_name\" content=\"Portal Amazonas 9\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-05T15:52:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-05T15:52:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/portalam9.com.br\/wp-content\/uploads\/2025\/12\/DNA-celulas-doenca-genetica-Josh-Hawley.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Reda\u00e7\u00e3o Portal AM9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Reda\u00e7\u00e3o Portal AM9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279\"},\"author\":{\"name\":\"Reda\u00e7\u00e3o Portal AM9\",\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/#\\\/schema\\\/person\\\/98ef830cc0fc3a08e33cb435efda505a\"},\"headline\":\"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo\",\"datePublished\":\"2025-12-05T15:52:08+00:00\",\"dateModified\":\"2025-12-05T15:52:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279\"},\"wordCount\":622,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/#\\\/schema\\\/person\\\/98ef830cc0fc3a08e33cb435efda505a\"},\"image\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/DNA-celulas-doenca-genetica-Josh-Hawley.webp\",\"articleSection\":[\"Health\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279\",\"url\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279\",\"name\":\"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo - Portal Amazonas 9\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/DNA-celulas-doenca-genetica-Josh-Hawley.webp\",\"datePublished\":\"2025-12-05T15:52:08+00:00\",\"dateModified\":\"2025-12-05T15:52:10+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/portalam9.com.br\\\/?p=4279\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#primaryimage\",\"url\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/DNA-celulas-doenca-genetica-Josh-Hawley.webp\",\"contentUrl\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/DNA-celulas-doenca-genetica-Josh-Hawley.webp\",\"width\":1200,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/?p=4279#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/portalam9.com.br\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/#website\",\"url\":\"https:\\\/\\\/portalam9.com.br\\\/\",\"name\":\"OV\u00e9rtice Portal\",\"description\":\"Portal de Noticias de Manaus\",\"publisher\":{\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/#\\\/schema\\\/person\\\/98ef830cc0fc3a08e33cb435efda505a\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/portalam9.com.br\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/portalam9.com.br\\\/#\\\/schema\\\/person\\\/98ef830cc0fc3a08e33cb435efda505a\",\"name\":\"Reda\u00e7\u00e3o Portal AM9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2026\\\/11\\\/logo-portalam9.png\",\"url\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2026\\\/11\\\/logo-portalam9.png\",\"contentUrl\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2026\\\/11\\\/logo-portalam9.png\",\"width\":343,\"height\":112,\"caption\":\"Reda\u00e7\u00e3o Portal AM9\"},\"logo\":{\"@id\":\"https:\\\/\\\/www.portalam9.com.br\\\/wp-content\\\/uploads\\\/2026\\\/11\\\/logo-portalam9.png\"},\"sameAs\":[\"https:\\\/\\\/portalam9.com.br\\\/\"],\"url\":\"https:\\\/\\\/www.portalam9.com.br\\\/?author=3\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo - Portal Amazonas 9","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/portalam9.com.br\/?p=4279","og_locale":"pt_BR","og_type":"article","og_title":"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo - Portal Amazonas 9","og_description":"Tempo de leitura: 3 minutos Um grupo de psiquiatras da Universidade de Leipzig, na Alemanha,","og_url":"https:\/\/portalam9.com.br\/?p=4279","og_site_name":"Portal Amazonas 9","article_published_time":"2025-12-05T15:52:08+00:00","article_modified_time":"2025-12-05T15:52:10+00:00","og_image":[{"width":1200,"height":800,"url":"https:\/\/portalam9.com.br\/wp-content\/uploads\/2025\/12\/DNA-celulas-doenca-genetica-Josh-Hawley.webp","type":"image\/webp"}],"author":"Reda\u00e7\u00e3o Portal AM9","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"Reda\u00e7\u00e3o Portal AM9","Est. tempo de leitura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/portalam9.com.br\/?p=4279#article","isPartOf":{"@id":"https:\/\/portalam9.com.br\/?p=4279"},"author":{"name":"Reda\u00e7\u00e3o Portal AM9","@id":"https:\/\/portalam9.com.br\/#\/schema\/person\/98ef830cc0fc3a08e33cb435efda505a"},"headline":"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo","datePublished":"2025-12-05T15:52:08+00:00","dateModified":"2025-12-05T15:52:10+00:00","mainEntityOfPage":{"@id":"https:\/\/portalam9.com.br\/?p=4279"},"wordCount":622,"commentCount":0,"publisher":{"@id":"https:\/\/portalam9.com.br\/#\/schema\/person\/98ef830cc0fc3a08e33cb435efda505a"},"image":{"@id":"https:\/\/portalam9.com.br\/?p=4279#primaryimage"},"thumbnailUrl":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2025\/12\/DNA-celulas-doenca-genetica-Josh-Hawley.webp","articleSection":["Health"],"inLanguage":"pt-BR","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/portalam9.com.br\/?p=4279#respond"]}]},{"@type":"WebPage","@id":"https:\/\/portalam9.com.br\/?p=4279","url":"https:\/\/portalam9.com.br\/?p=4279","name":"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo - Portal Amazonas 9","isPartOf":{"@id":"https:\/\/portalam9.com.br\/#website"},"primaryImageOfPage":{"@id":"https:\/\/portalam9.com.br\/?p=4279#primaryimage"},"image":{"@id":"https:\/\/portalam9.com.br\/?p=4279#primaryimage"},"thumbnailUrl":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2025\/12\/DNA-celulas-doenca-genetica-Josh-Hawley.webp","datePublished":"2025-12-05T15:52:08+00:00","dateModified":"2025-12-05T15:52:10+00:00","breadcrumb":{"@id":"https:\/\/portalam9.com.br\/?p=4279#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/portalam9.com.br\/?p=4279"]}]},{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/portalam9.com.br\/?p=4279#primaryimage","url":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2025\/12\/DNA-celulas-doenca-genetica-Josh-Hawley.webp","contentUrl":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2025\/12\/DNA-celulas-doenca-genetica-Josh-Hawley.webp","width":1200,"height":800},{"@type":"BreadcrumbList","@id":"https:\/\/portalam9.com.br\/?p=4279#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/portalam9.com.br\/"},{"@type":"ListItem","position":2,"name":"Gene \u00fanico pode estar ligado a doen\u00e7as mentais, sugere estudo"}]},{"@type":"WebSite","@id":"https:\/\/portalam9.com.br\/#website","url":"https:\/\/portalam9.com.br\/","name":"OV\u00e9rtice Portal","description":"Portal de Noticias de Manaus","publisher":{"@id":"https:\/\/portalam9.com.br\/#\/schema\/person\/98ef830cc0fc3a08e33cb435efda505a"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/portalam9.com.br\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":["Person","Organization"],"@id":"https:\/\/portalam9.com.br\/#\/schema\/person\/98ef830cc0fc3a08e33cb435efda505a","name":"Reda\u00e7\u00e3o Portal AM9","image":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2026\/11\/logo-portalam9.png","url":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2026\/11\/logo-portalam9.png","contentUrl":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2026\/11\/logo-portalam9.png","width":343,"height":112,"caption":"Reda\u00e7\u00e3o Portal AM9"},"logo":{"@id":"https:\/\/www.portalam9.com.br\/wp-content\/uploads\/2026\/11\/logo-portalam9.png"},"sameAs":["https:\/\/portalam9.com.br\/"],"url":"https:\/\/www.portalam9.com.br\/?author=3"}]}},"_links":{"self":[{"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/posts\/4279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4279"}],"version-history":[{"count":1,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/posts\/4279\/revisions"}],"predecessor-version":[{"id":4281,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/posts\/4279\/revisions\/4281"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=\/wp\/v2\/media\/4280"}],"wp:attachment":[{"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.portalam9.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}