{"id":3919,"date":"2025-09-30T14:20:37","date_gmt":"2025-09-30T17:20:37","guid":{"rendered":"https:\/\/overticeportal.com.br\/?p=3919"},"modified":"2025-09-30T14:24:53","modified_gmt":"2025-09-30T17:24:53","slug":"reposicao-de-vitamina-c-no-cerebro-atrasa-inicio-e-a-progressao-da-doenca-de-alzheimer-conclui-estudo","status":"publish","type":"post","link":"https:\/\/www.portalam9.com.br\/?p=3919","title":{"rendered":"Reposi\u00e7\u00e3o de vitamina C no c\u00e9rebro “atrasa in\u00edcio e a progress\u00e3o” da Doen\u00e7a de Alzheimer, conclui estudo"},"content":{"rendered":"\n

Tempo de leitura: 3 minutos <\/em><\/p>\n\n\n\n

Cientistas do <\/strong>Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto (i3S) <\/strong><\/a>descobriram que a reposi\u00e7\u00e3o de vitamina C nas c\u00e9lulas imunit\u00e1rias do c\u00e9rebro atrasa o in\u00edcio e a progress\u00e3o da Doen\u00e7a de Alzheimer.<\/strong><\/p>\n\n\n\n

A equipa do i3S “descobriu que o transporte e consequente normaliza\u00e7\u00e3o da concentra\u00e7\u00e3o da vitamina C dentro das c\u00e9lulas da microglia — o sistema imunit\u00e1rio do c\u00e9rebro — em modelos pr\u00e9-cl\u00ednicos da doen\u00e7a de Alzheimer, restabelece o funcionamento normal destas c\u00e9lulas e atrasa o in\u00edcio e a progress\u00e3o da doen\u00e7a<\/em>“, descreve a institui\u00e7\u00e3o, numa nota de imprensa enviada \u00e0 Lusa.<\/p>\n\n\n\n

Camila Portugal, primeira autora do estudo, publicado este m\u00eas na revista cient\u00edfica Redox Biology<\/strong><\/a>, explica que a equipa mostrou que, repondo os n\u00edveis de vitamina C na microglia, foi poss\u00edvel “restabelecer o funcionamento normal destas c\u00e9lulas no c\u00e9rebro com Doen\u00e7a de Alzheimer”<\/strong>.<\/p>\n\n\n\n

\n

“Mais importante, os dados indicam que isso parece ser suficiente n\u00e3o s\u00f3 para atrasar o in\u00edcio da doen\u00e7a, mas tamb\u00e9m para atrasar a progress\u00e3o da doen\u00e7a quando esta j\u00e1 come\u00e7ou a manifestar-se, acrescentou.Jo\u00e3o Relvas, l\u00edder do grupo que desenvolveu a investiga\u00e7\u00e3o no i3S e professor da Faculdade de Medicina do Porto (FMUP), observa que ficou tamb\u00e9m demonstrado “que \u00e9 a capta\u00e7\u00e3o e n\u00e3o a suplementa\u00e7\u00e3o da vitamina C que \u00e9 cr\u00edtica”.<\/p>\n<\/blockquote>\n\n\n\n

“Ou seja, por mais vitamina C que possamos ingerir, se n\u00e3o tivermos a maquinaria de transporte a funcionar, ela n\u00e3o entra nas c\u00e9lulas da microglia e o seu efeito \u00e9 nulo<\/em>“, assegurou.<\/p>\n\n\n\n

O docente diz ter dados “que indicam que\u00a0a diminui\u00e7\u00e3o do transporte da vitamina C est\u00e1 associada \u00e0 neuroinflama\u00e7\u00e3o noutras doen\u00e7as neurodegenerativas”, como por exemplo na Doen\u00e7a de Parkinson, pelo que, “esta abordagem poder\u00e1 eventualmente ser transposta para outras doen\u00e7as” e j\u00e1 h\u00e1 “alguns dados experimentais que suportam essa estrat\u00e9gia<\/strong><\/em>“<\/strong>.<\/p>\n\n\n\n

Para Renato Socodato, que integra a equipa do grupo Glial Cell Biology do i3S, “este transportador pode ser considerado um alvo terap\u00eautico<\/strong>“.<\/em><\/p>\n\n\n\n

No estudo, os investigadores recorreram “\u00e0 engenharia gen\u00e9tica para aumentar a express\u00e3o do transportador e, consequentemente, a capta\u00e7\u00e3o da vitamina C pela microglia<\/em>“, mas, no futuro, pretendem usar agentes farmacol\u00f3gicos. “Idealmente, o doente tomaria um medicamento que aumentaria o n\u00edvel do transportador e a capta\u00e7\u00e3o de vitamina C da microglia, o que conferiria alguma prote\u00e7\u00e3o contra a Doen\u00e7a de Alzheimer”<\/em>, explicou.<\/p>\n\n\n\n

\n

“A equipa est\u00e1 j\u00e1 a avaliar milhares de compostos farmacol\u00f3gicos com o objetivo de encontrar uma mol\u00e9cula que possa manter os n\u00edveis adequados do transportador e, consequentemente, de vitamina C dentro das c\u00e9lulas”.<\/p>\n<\/blockquote>\n\n\n\n

O i3S descreve que a vitamina C \u00e9 essencial para o normal funcionamento do c\u00e9rebro<\/strong>, “atuando como um poderoso antioxidante que protege os neur\u00f3nios e as c\u00e9lulas da glia, incluindo as da microglia”.<\/p>\n\n\n\n

\n

“A vitamina C \u00e9 captada na forma de ascorbato atrav\u00e9s de um transportador espec\u00edfico (o SVCT2) para dentro das c\u00e9lulas de microglia, que funcionam como o sistema imunit\u00e1rio do c\u00e9rebro e s\u00e3o importantes para o seu desenvolvimento, manuten\u00e7\u00e3o e resposta a traumas ou doen\u00e7as”, referiu.<\/p>\n<\/blockquote>\n\n\n\n

Durante o envelhecimento, e em contextos de patologia como na Doen\u00e7a de Alzheimer, “os n\u00edveis de vitamina C no c\u00e9rebro diminuem e n\u00e3o conseguem ser repostos adequadamente nem por suplementa\u00e7\u00e3o oral nem por via endovenosa”.<\/em><\/p>\n\n\n\n

Fonte: Sic Not\u00edcias \/ <\/strong>Foto: GSO Images<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Tempo de leitura: 3 minutos Cientistas do Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade<\/p>\n","protected":false},"author":3,"featured_media":3920,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[],"class_list":["post-3919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"\nReposi\u00e7\u00e3o de vitamina C no c\u00e9rebro "atrasa in\u00edcio e a progress\u00e3o" da Doen\u00e7a de Alzheimer, conclui estudo - Portal Amazonas 9<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.portalam9.com.br\/?p=3919\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reposi\u00e7\u00e3o de vitamina C no c\u00e9rebro "atrasa in\u00edcio e a progress\u00e3o" da Doen\u00e7a de Alzheimer, conclui estudo - 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