{"id":3751,"date":"2025-09-22T15:58:42","date_gmt":"2025-09-22T18:58:42","guid":{"rendered":"https:\/\/overticeportal.com.br\/?p=3751"},"modified":"2025-09-22T15:59:34","modified_gmt":"2025-09-22T18:59:34","slug":"estudo-revela-elo-genetico-entre-peixes-e-a-formacao-de-dedos-humanos","status":"publish","type":"post","link":"https:\/\/www.portalam9.com.br\/?p=3751","title":{"rendered":"Estudo revela elo gen\u00e9tico entre peixes e a forma\u00e7\u00e3o de dedos humanos"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Tempo de leitura: 2 minutos <\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">H\u00e1 quase 360 milh\u00f5es de anos, os peixes ancestrais foram da \u00e1gua para a terra, gerando um processo que transformaria suas nadadeiras em p\u00e9s e m\u00e3os com dedos. Segundo um estudo realizado por pesquisadores internacionais, uma sequ\u00eancia de DNA chamada 5DOM \u00e9 o elo gen\u00e9tico entre os animais e humanos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A pesquisa foi liderada pela Universidade de Genebra, na Su\u00ed\u00e7a, em parceria com as Universidades de Harvard e Chicago, nos Estados Unidos, e o Coll\u00e8ge de France. A descoberta foi publicada na revista cient\u00edfica Nature na \u00faltima quarta-feira (17\/9).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Atrav\u00e9s do sistema de edi\u00e7\u00e3o gen\u00e9tica CRISPR, pesquisadores descobriram que m\u00e3os e p\u00e9s humanos n\u00e3o surgiram de um gene novo, mas sim da reutiliza\u00e7\u00e3o e novas combina\u00e7\u00f5es de peda\u00e7os <em>\u201cvelhos\u201d<\/em> de um c\u00f3digo gen\u00e9tico j\u00e1 existente.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Compara\u00e7\u00e3o de genomas de peixes e roedores<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Por muito tempo, cientistas buscam entender como peixes ancestrais com nadadeiras se \u201c<em>transformaram\u201d<\/em> em vertebrados com pulm\u00f5es, p\u00e9s e m\u00e3os.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Para isso, o estudo mais recente analisou genes e as regi\u00f5es n\u00e3o codificantes do genoma de peixes-zebra. Essa regi\u00e3o n\u00e3o produz prote\u00ednas, mas \u00e9 respons\u00e1vel por controlar quando e onde ser\u00e3o ativados os genes, funcionando como \u201c<em>torres de controle<\/em>\u201d gen\u00e9ticas, decidindo se o gene ser\u00e1 ligado ou desligado.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Em seguida, os pesquisadores compararam genomas dos peixes e camundongos. Eles encontraram uma regi\u00e3o regulat\u00f3ria igual, ligada ao desenvolvimento de dedos nos roedores e chamada 5DOM.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ao remover essa regi\u00e3o dos peixes atrav\u00e9s da ferramenta gen\u00e9tica CRISPR, os genes pararam de ser ativos na cloaca, mas n\u00e3o nas nadadeiras do animal aqu\u00e1tico. Isso sugere que a regi\u00e3o onde ficam os sistemas intestinal, urin\u00e1rio e reprodutor dos peixes foi \u201c<em>reaproveitada<\/em>\u201d para ajuda na forma\u00e7\u00e3o de dedos em animais terrestres.<\/p>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_3971579\"><img decoding=\"async\" src=\"https:\/\/uploads.metroimg.com\/wp-content\/uploads\/2025\/09\/22134738\/dedos-humanos.jpg\" alt=\"Imagem colorida de dedos humanos - Metr\u00f3poles \" class=\"wp-image-3971579\"\/><figcaption class=\"wp-element-caption\">Segundo pesquisa, dedos humanos foram \u201ccriados\u201d atrav\u00e9s de mecanismo gen\u00e9tico visto nos peixes<\/figcaption><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u201cA caracter\u00edstica comum entre a cloaca e os dedos \u00e9 que eles representam partes terminais. \u00c0s vezes, s\u00e3o a extremidade de tubos no sistema digestivo, \u00e0s vezes a extremidade de p\u00e9s e m\u00e3os, ou seja, dedos. Portanto, ambos marcam o fim de algo\u201d, diz a autora principal do estudo, Aur\u00e9lie Hintermann, da Universidade de Genebra, em comunicado.<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">O resultado surpreendeu os cientistas, que refizeram o experimento, mas desta vez retirando o 5DOM dos camundongos. Eles perceberam que a sequ\u00eancia de DNA agiu na mesma regi\u00e3o vista nos peixes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ap\u00f3s a descoberta, a equipe de pesquisa pretende analisar como aconteceu o reaproveitamento gen\u00e9tico com o passar dos milh\u00f5es de anos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Fonte: Metr\u00f3poles <strong>\/ <\/strong>Foto: Getty Images<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tempo de leitura: 2 minutos H\u00e1 quase 360 milh\u00f5es de anos, os peixes ancestrais foram<\/p>\n","protected":false},"author":3,"featured_media":3752,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-3751","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-curiosidades-2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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